Brechka N.
PhD in Biology, Senior Research Officer of the endocrinology of the laboratory
pharmacology of SI “Institute for Endocrine Pathology Problems named after V.Ya.
Danilevsky of the National Academy of Medical Science of Ukraine”, Kharkiv,
Ukraine.
Strilets O.
GrandPhD in Pharmacy, Professor of the Department of Biotechnology, National
University of Pharmacy, Kharkiv, Ukraine
Kaliuzhnaia O.
PhD in Pharmacy, Associate Professor of the Department of Biotechnology,
National University of Pharmacy, Kharkiv, Ukraine
Strelnikov L.
GrandPhD in Pharmacy, Professor of the Department of Biotechnology, National
University of Pharmacy, Kharkiv, Ukraine
Shcherbak O.
PhD in Biology, Dean of the faculty of Biotechnology and environmental sciences
of Kharkiv State Zoo-Veterinary Academy, Kharkiv, Ukraine.
ULTRASTRUCTURE OF LEIDIG AND SERTOLI CELLS AFTER
EXPOSURE OF X-RAY RADIATION
Introduction. The main problem that occurs during radiation therapy is a
radiation exposure affects not only the tumor, but also the neighboring healthy tissue.
The consequences after the procedure come into being after some time, and the degree
of their severity depends on the size and type of malignancy and the location of the
tumor. Radiation has adverse effects to spermatogenesis and therefore it affects on the
ability to conceive of animals and humans. However, radiation therapy is widely used
because there is no other chance for treating certain cancers of children and adults [1].
The authors of the most scientific papers have a single opinion cells of testes
(specifically basal membrane of the tubules and spermatogonia) quickly depleted after
irradiation. Spermatocytes are the most resistant to radiation, the next ones for
resistance are spermatids and mature sperm cells.
Direct exposure to the testicles at lower doses can affect the germinal epithelium,
but at large doses it can cause either reversible or irreversible aspermia [2]. Testicular
irradiation can lead to changes levels of luteinizing and folliclestimulating hormones
in animals serum [3]. Radiation can lead to disruption of spermatogenesis,
desquamation, vacuolization of germ cells and the emergence multinucleated giant
cells also. The type and extent of these changes depends on dose, duration and
frequency of radiation [4]. Irradiation of the testicles can cause DNA damage in both
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