INTRODUCTION
The fifth volume of the monograph includes 27 sections, each of which is devoted
to a specific problem of national economy’s sustainable development.
The first section “POSTNATAL GROWTH RESTRICTION IN NEONATES
WITH VLBW AND ELBW DURING NEONATAL HOSPITAL STAY”. Postnatal
growth restriction (PGR) is a worldwide problem for premature infants with very low
birth weight (VLBW, 1000-1499g) and extremely low birth weight (ELBW, under
999g) which determines poor long-term forecast for the physical and intellectual
development in later life. Evaluation of postnatal growth parameters – body weight
(BW), body length (BL) and head circumference (HC) – was conducted at birth,
admission to neonatology department and discharge. The research included 92 infants
with VLBW and 34 infants with ELBW. 76.47% of infants with ELBW and 39.13%
of infants with VLBW required treatment in neonatal intensive care unit before
admission to neonatology department. Infants with VLBW and ELBW had severe
growth restriction at discharge by BW – 40.2% vs 64.7%; by BL – 41.3% vs 67.7%;
by HC – 16.3% vs 23.5%. PGR increases from birth to discharge by every parameter
in both groups, which requires collective research efforts for the development of new
nutritional strategies.
The second section “THE TOPICAL PHARMACEUTICAL COMPOSITION
FOR TREATMENT OF DIABETIC SKIN LESIONS”. Diabetes mellitus causes the
increasing f number and severity of complications of different organs and systems, skin
among others. Topical treatment of diabetic skin lesions is realized with using topical
reparative medicines which are not always provide the achievement of the adequate
therapeutical effect. The topical soft pharmaceutical composition based on succinic
acid derivate has been developed in
SI “Institute for endocrine pathology problems
named after V. Ya. Danilevsky of the
National Academy of Medical Sciences of
Ukraine”. As it was early determined, succinic acid derivate is able to influence the
main pathogenic mechanisms development of diabetes complications. The
pharmaceutical composition and manufacturing technology of the new medicine on the
o/w emulsion base have been elaborated. The analytical quality control methods have
been proposed. The ability of the soft pharmaceutical composition based on succinic
acid derivate on exudative and alterative inflammation phases in the presence and
absence of experimentally induced diabetes has been determined.
The third section “MODERN ASPECTS OF CREATING THE ALLERGENS
FOR THE IMMUNODIAGNOSTICS OF CANDIDAMYCOSIS”. As of today in
Ukraine there are no allergens available for the candidamycosis diagnostics, and the
range of imported allergens is quite limited and expensive, which conditions the
research works in the creation of the national allergen for the candidamycosis
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