diagnostics. The Paper is aimed at the elaboration of the allergen obtainment
technology for the immunodiagnostics of candida infection. The Paper provides the
experimental grounding of the optimal technology of extracting the protein and
polysaccharide from the biomass of C.Albicans fungus through the combination of
physical and chemical methods: Extraction with 5.0 % solution of sodium hydroxide
with ultrasound. According to the results the biochemical research the content of
obtained C. Albicans fungus extract was determined, which contains the proteins,
polysaccharides and nucleic acids. The monosaccharide composition of
polysaccharides was determined, which contains mannose, glucose, and tracks of
ribose. Taking into account that the low-molecular substances may influence the results
of immunodiagnostics of candida infection, physical, chemical and biological
researches ground the technology of purification of C.Albicans fungus extract from the
ballast low-molecular substances using the gel chromatography on Sephadex G-100.
Based on the results of biological researches on the simulated generalized
candidamycosis of guinea pigs the high-molecular fraction was selected, which, in case
of the intradermal administration in the amount of 0.1 ml with the protein concentration
of 5 µg/ml in 24-48 hours causes the formation of erythema 18-22 mm and papula 5-
10 mm, i.e. causes the delayed-type reaction.
The fourth section “ANALYSIS OF MODERN ANTI-ACNE REMEDIES FOR
CREATION THE COMPLEX BIOTECHNOLOGICAL DRUG FOR ACNE
TREATMENT”. Modern remedies for problem skin with acne and postacne are
symptomatic, such as antibiotics for treatment of inflammation, or alcoholic mixtures
for sebum removal. However, skin microflora becomes resistant to antibiotic, the
alcohol overdry the skin, and sebum removal accompanied by violation of lipid barrier
of the skin. Insufficiently attention is given to problem of skin microflora, which is
associated with infectious-inflammatory process that develops with acne, or occurs as
consequence of treatment with anti-inflammatory remedies. Solution of these problems
is therapeutic and prophylactic remedy of complex action, which suppress pathogenic
and opportunistic microflora, treating inflammation, remove sebum, and normalize
skin microflora.
The fifth section “SINGULAR INTEGRAL EQUATIONS IN MODEL
BOUNDARY VALUE PROBLEMS WITH CONICAL GEOMETRY”. Mathematical
modeling plays an important role in the analysis of various processes. Theoretical
studying and development of mathematical models that adequate to processes make
possible not only to validate, but also often to predict results of experimental
investigations of these processes. In the article the rigorous mathematical method of
the model boundary value problems solution for acoustics and electrodynamics based
on the application of Kontorovich–Lebedev integral transforms in combination with
the method of the singular integral equations is proposed and developed. It is shown
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