Kustova S.
Candidate of Pharmaceutical Sciences,
Senior Research Officer, Department
Head of the pharmaceutical technology division of the laboratory for analytical and
physicochemical researches of SI “Institute for endocrine pathology problems named
after V. Ya. Danilevsky of the
National Academy of Medical Sciences of Ukraine”,
Kharkiv, Ukraine
Boiko M.
Candidate of Pharmaceutical Sciences,
Senior Research Officer of the
pharmaceutical technology division of the laboratory for analytical and
physicochemical researches of SI “Institute for endocrine pathology problems named
after V. Ya. Danilevskyof of the
National Academy of Medical Sciences of Ukraine”,
Kharkiv, Ukraine
THE TOPICAL PHARMACEUTICAL COMPOSITION FOR
TREATMENT OF DIABETIC SKIN LESIONS
Introduction. Diabetes mellitus is considered to be a global medical and social
problem of the XXI century. According to the data of the International Diabetic
Federation, there are more than 370 million people with diabetes all around the world.
Due to increasing of the human population and life duration, urbanization and
hypodynamical life style, the spreading of the diabetes becomes epidemic. Thus, before
2030 the increasing of diabetic population up to 500 million patients is expected. As
for Ukraine, the statistic data shows more than 1,5 million people with diabetes, but it
is considered this figure to be significantly lowered. Now the number of diabetic
patients has exceeded 2 million and is expected to be increased yearly.
Unfortunately, the number of diabetes related complications such as neuropathy,
retinopathy, cardiac and kidney disturbances is increasing, too. The diabetes
complications are the main cause of the patients´s invalidization and mortality.
It is necessary to point out that skin has to be pathologically and specifically
changed in diabetic patients. Skin injuries are nonspecific diabetes complications and
are registered in approximately 30 % patients. Sometimes the appearances of
dermatological symptoms, especially itching, dry skin and mucous, repeatitive skin
infections may detect the first manifestation of diabetes.
The diabetes skin injuries have various ethiology. Nowadays, more than 30 kinds
of skin lesions inter-related in diabetes have been described. They are conditionally
divided on 3 groups: the lowering of skin protective function (infectious diseases –
folliculutis, cellulitis, abscesses and fungal skin infections); the skin trophic changes
(dry skin, eruptive xanthomatosis) and the skin pathologies occurring as a result of
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