Rybalkin M.
PhD of Pharmacy, Assistant Professor of the Department of Biotechnology,
National University of Pharmacy, Kharkiv, Ukraine
Strelnikov L.
Doctor of Pharmacy, Chair of the Department of Biotechnology, National
University of Pharmacy, Kharkiv, Ukraine
MODERN ASPECTS OF CREATING THE ALLERGENS FOR THE
IMMUNODIAGNOSTICS OF CANDIDAMYCOSIS
Introduction. During the last years the number of patients suffering from
candidamycosis dramatically increased. As most researchers state, the growth of the
candidamycosis is conditioned by the long-lasting and irrational application of
medicines, influencing the immune system, unfavorable ecological factors and
strengthening of pathogenicity of the yeast-like fungi themselves.
The Candida fungi cause the whole set of infectious diseases – from local damage
of mucous membranes and skin to the life-threatening disseminated infectious
processes with the essential damage of internal organs and systems. For a physician the
problem of fungal infections is constituted by the fact that they cannot be easily
diagnosed, since the clinical symptoms are non-specific, is hardly-curable and
frequently leads to the lethal outcome. Now it is widely recognized that the
immunological reactions with the allergens in case of candidamycosis may be used for
the diagnostics and predictions. However, despite urgent necessity of diagnostic
allergens, as of now, there is no national or imported registered allergen available in
Ukraine; their assortment is quite limited and expensive for the diagnostics of
candidamycosis. Thus, the elaboration of the new allergen technology for the
immunodiagnostics of candida infection is poignant for national industry.
Constant growth of the patients suffering from candidia infection, symptom-free
progress of the latent diseases, conditions the searching and creation of the new
medicines for the diagnostics of candidamycosis satisfying the modern requirements:
Specificity, stability during storage, absence of toxic influence. The solution of this
problem is possible through the creation of allergen for the immunodiagnostics of
candida infection.
Modern condition of candida infection frequency. For the last 10-15 years the
attention of many researchers is focused on the study of candidamycosis of human and
animals occurring during the organism colonization by Candida, the yeast-like fungi
[1, 8]. These diseases are well-known under different names: Sooromycosis,
Moniliasis, Levurosis and Thrush [2]. As most researchers state, the growth of the
candidamycosis is conditioned by the long-lasting and irrational application of
- 1500 -