•
Reduces the thickness of the surface layer of the epidermis - when applied to
the skin isotretinoin has a weak irritant effect on the cells of the stratum corneum,
causing them to dry out and decrease (peeling effect). This leads to a decrease in the
thickness of the surface horny layer of the epidermis, consisting of dead cells. This
makes the pores open to the skin, which prevents the formation of pores of fat stroke
(acne).
•
Comedonolytic properties - isotretinoin dissolves the substance of the fat cups
that clog pores of the skin. This leads to skin cleansing of acne, as well as contributes
to the prevention of acne formation.
•
Reduces the activity of the sebaceous glands - one of the major factors in the
formation of acne and acne is the increased function of the sebaceous glands, the ducts
of which open to hair follicles, which are in the pores of the skin. Increasing the
production of fatty secretion contributes to occlusion of pores. Isotretinin normalizes
the function of the sebaceous glands of the skin, reducing their secretion [2, 5, 7, 10].
CONCLUSION
The modern market is full of various forms of medicinal, therapeutic and
prophylactic and cosmetic products designed to care for a problem skin of the face,
prone to manifestations of acne and poxone. In the arsenal of dermatologists, a
significant percentage is taken by symptomatic means, for example, antibiotics for the
treatment of inflammation caused by microorganisms, or alcoholic mixtures for the
removal of excess sebum. However, the skin of the microflora gradually becomes
resistant to the antibiotic, alcohol cleanses the skin, and the removal of sebum is
inevitably accompanied by the dissolution of part of the epidermal lipids, violating the
integrity of the lipid barrier of the skin. In addition, attention should be paid to the
problem of the microflora of the skin, which is associated with the infectious-
inflammatory process that develops in acne, or occurs as a consequence of treatment
with anti-inflammatory drugs. In turn, keeping the microflora of the skin at the normal
level will contribute to more effective protection against the infectious form of acne
and the prevention of the disease and its relapse.
The solution of these problems is the use of therapeutic and preventive measures
of complex action that will affect various aspects of dermatological problems,
simultaneously suppressing pathogenic and opportunistic microflora, treating
inflammation, removing excess of sebum, and normalizing the microflora of the skin.
But for today there is no such complex composition, therefore the development of the
composition and technology of a complex drug with a probiotic for the treatment of
dermatological diseases is relevant.
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